Cloned (Comment) | Organism |
---|---|
h-isoQC, lacking the N-terminal signal anchor and the short cytosolic tail, is expressed as a fusion protein in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Homo sapiens | |
benzimidazole | - |
Homo sapiens | |
benzylimidazole | - |
Homo sapiens | |
cysteamine | - |
Homo sapiens | |
EDTA | - |
Homo sapiens | |
H-Gln-7-amido-4-methylcoumarin | substrate inhibition | Homo sapiens | |
H-Gln-beta-naphthylamide | substrate inhibition | Homo sapiens | |
imidazole | - |
Homo sapiens | |
methylimidazole | - |
Homo sapiens | |
N-dimethylcysteamine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
H-Gln-7-amido-4-methylcoumarin | pH 8.0, 30°C | Homo sapiens | |
0.036 | - |
H-Gln-beta-naphthylamide | pH 8.0, 30°C | Homo sapiens | |
0.115 | - |
H-Gln-Gln-OH | pH 8.0, 30°C | Homo sapiens | |
0.214 | - |
H-Gln-Gly-Pro-OH | pH 8.0, 30°C | Homo sapiens | |
0.424 | - |
H-Gln-Gly-OH | pH 8.0, 30°C | Homo sapiens | |
0.705 | - |
H-Gln-Glu-OH | pH 8.0, 30°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | exclusively localized within the Golgi complex, obviously retained by the N-terminus. Retention in the Golgi complex suggests involvement in the protein maturation machinery | Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | ubiquitous expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gln-Gln | - |
Homo sapiens | 5-oxoprolyl-Gln + NH3 | - |
? | |
Gln-Gly | - |
Homo sapiens | 5-oxoprolyl-Gly + NH3 | - |
? | |
H-Gln-7-amido-4-methylcoumarin | - |
Homo sapiens | 5-oxoprolyl-7-amido-4-methylcoumarin + NH3 | - |
? | |
H-Gln-beta-naphthylamide | - |
Homo sapiens | 5-oxoprolyl-beta-naphthylamide + NH3 | - |
? | |
H-Gln-Glu-OH | - |
Homo sapiens | 5-oxoprolyl-Glu-OH + NH3 | - |
? | |
H-Gln-Gly-Pro-OH | - |
Homo sapiens | 5-oxoprolyl-Gly-Pro-OH + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutaminyl cyclase | - |
Homo sapiens |
h-isoQC | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.07 | - |
H-Gln-7-amido-4-methylcoumarin | pH 8.0, 30°C | Homo sapiens | |
1.66 | - |
H-Gln-Gly-OH | pH 8.0, 30°C | Homo sapiens | |
2.65 | - |
H-Gln-Glu-OH | pH 8.0, 30°C | Homo sapiens | |
2.72 | - |
H-Gln-Gln-OH | pH 8.0, 30°C | Homo sapiens | |
3.4 | - |
H-Gln-beta-naphthylamide | pH 8.0, 30°C | Homo sapiens | |
4.02 | - |
H-Gln-Gly-Pro-OH | pH 8.0, 30°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0073 | - |
benzylimidazole | pH 8.0, 30°C | Homo sapiens | |
0.022 | - |
N-dimethylcysteamine | pH 8.0, 30°C | Homo sapiens | |
0.068 | - |
cysteamine | pH 8.0, 30°C | Homo sapiens | |
0.079 | - |
methylimidazole | pH 8.0, 30°C | Homo sapiens | |
0.199 | - |
benzimidazole | pH 8.0, 30°C | Homo sapiens | |
0.219 | - |
imidazole | pH 8.0, 30°C | Homo sapiens | |
1.47 | - |
H-Gln-beta-naphthylamide | - |
Homo sapiens | |
5.73 | - |
H-Gln-7-amido-4-methylcoumarin | - |
Homo sapiens |