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Literature summary for 2.3.2.5 extracted from

  • Schilling, S.; Lindner, C.; Koch, B.; Wermann, M.; Rahfeld, J.U.; von Bohlen, A.; Rudolph, T.; Reuter, G.; Demuth, H.U.
    Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization (2007), Biochemistry, 46, 10921-10930.
    View publication on PubMed
Search for more literature for 2.3.2.5

Cloned(Commentary)

Cloned (Comment) Organism
heterologously expressed in Pichia pastoris and Escherichia coli Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
1-Benzylimidazole isoDromeQC Drosophila melanogaster
1-Methylimidazole isoDromeQC Drosophila melanogaster
4-methylimidazole
-
 Drosophila melanogaster
benzimidazole isoDromeQC Drosophila melanogaster
cysteamine isoDromeQC Drosophila melanogaster
imidazole isoDromeQC Drosophila melanogaster
L-glutamine-4-nitroanilide substrate inhibition; substrate inhibition, isoDromeQC Drosophila melanogaster
N-diethylcysteamine
-
 Drosophila melanogaster
N-dimethylcysteamine isoDromeQC Drosophila melanogaster
N-omega-acetylhistamine isoDromeQC Drosophila melanogaster
P150/03 isoDromeQC Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
 H-Gln-Glu-Tyr-Phe-NH2 30°C Drosophila melanogaster
0.08
-
 H-Gln-Lys-Arg-Leu-NH2 30°C Drosophila melanogaster
0.128
-
 H-Gln-Phe-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
0.1293
-
 H-Gln-Val-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
0.14
-
 H-Gln-Val-Ala-OH 30°C Drosophila melanogaster
0.15
-
 H-Gln-beta-naphthylamide 30°C, isoDromeQC Drosophila melanogaster
0.17
-
 H-Gln-beta-naphthylamide 30°C Drosophila melanogaster
0.205
-
 L-glutaminyl-7-amido-4-methylcoumarin 30°C, isoDromeQC Drosophila melanogaster
0.31
-
 L-glutaminyl-7-amido-4-methylcoumarin 30°C Drosophila melanogaster
0.35
-
 H-Gln-Phe-Ala-OH 30°C Drosophila melanogaster
0.42
-
 H-Gln-Glu-Ala-Phe-NH2 30°C Drosophila melanogaster
0.68
-
 H-Gln-Glu-Ala-Phe-NH2 30°C, isoDromeQC Drosophila melanogaster
0.72
-
 H-Gln-Tyr-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
0.94
-
 H-Gln-Gln-OH 30°C, isoDromeQC Drosophila melanogaster
1.17
-
 H-Gln-Gly-Pro-OH 30°C, isoDromeQC Drosophila melanogaster
1.5
-
 H-Gln-Gln-OH 30°C Drosophila melanogaster
2.3
-
 H-Gln-Asp-Glu-Leu-NH2 30°C Drosophila melanogaster
2.4
-
 H-Gln-Gly-OH 30°C, isoDromeQC Drosophila melanogaster
2.8
-
 H-Gln-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
4.1
-
 H-Gln-Gly-Pro-OH 30°C Drosophila melanogaster
5
-
 H-Gln-Ala-OH 30°C Drosophila melanogaster
7.1
-
 H-Gln-Gly-OH 30°C Drosophila melanogaster
29.5
-
 H-Gln-Glu-OH 30°C Drosophila melanogaster

Metals/Ions

Metals/Ions Comment Organism Structure
Zn equimolar protein-bound zinc Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Drosophila melanogaster Q9VRQ9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gln-Gln
-
 Drosophila melanogaster 5-oxoprolyl-Gln + NH3
-
 ?
Gln-Gln isoDromeQC Drosophila melanogaster 5-oxoprolyl-Gln + NH3
-
 ?
Gln-Gly
-
 Drosophila melanogaster 5-oxoprolyl-Gly + NH3
-
 ?
Gln-Gly isoDromeQC Drosophila melanogaster 5-oxoprolyl-Gly + NH3
-
 ?
H-Gln-Ala-OH
-
 Drosophila melanogaster 5-oxoprolyl-Ala-OH + NH3
-
 ?
H-Gln-Ala-OH isoDromeQC Drosophila melanogaster 5-oxoprolyl-Ala-OH + NH3
-
 ?
H-Gln-Asp-Glu-Leu-NH2
-
 Drosophila melanogaster 5-oxoprolyl-Asp-Glu-Leu-NH2 + NH3
-
 ?
H-Gln-Asp-Glu-Leu-NH2 isoDromeQC Drosophila melanogaster 5-oxoprolyl-Asp-Glu-Leu-NH2 + NH3
-
 ?
H-Gln-beta-naphthylamide
-
 Drosophila melanogaster 5-oxoprolyl-beta-naphthylamide + NH3
-
 ?
H-Gln-beta-naphthylamide isoDromeQC Drosophila melanogaster 5-oxoprolyl-beta-naphthylamide + NH3
-
 ?
H-Gln-Glu-Ala-Phe-NH2
-
 Drosophila melanogaster 5-oxoprolyl-Glu-Ala-Phe-NH2 + NH3
-
 ?
H-Gln-Glu-Ala-Phe-NH2 isoDromeQC Drosophila melanogaster 5-oxoprolyl-Glu-Ala-Phe-NH2 + NH3
-
 ?
H-Gln-Glu-OH
-
 Drosophila melanogaster 5-oxoprolyl-Glu-OH + NH3
-
 ?
H-Gln-Glu-OH isoDromeQC Drosophila melanogaster 5-oxoprolyl-Glu-OH + NH3
-
 ?
H-Gln-Glu-Tyr-Phe-NH2
-
 Drosophila melanogaster 5-oxoprolyl-Glu-Tyr-Phe-NH2 + NH3
-
 ?
H-Gln-Glu-Tyr-Phe-NH2 isoDromeQC Drosophila melanogaster 5-oxoprolyl-Glu-Tyr-Phe-NH2 + NH3
-
 ?
H-Gln-Gly-Pro-OH
-
 Drosophila melanogaster 5-oxoprolyl-Gly-Pro-OH + NH3
-
 ?
H-Gln-Gly-Pro-OH isoDromeQC Drosophila melanogaster 5-oxoprolyl-Gly-Pro-OH + NH3
-
 ?
H-Gln-Lys-Arg-Leu-NH2
-
 Drosophila melanogaster 5-oxoprolyl-Lys-Arg-Leu-NH2 + NH3
-
 ?
H-Gln-Lys-Arg-Leu-NH2 isoDromeQC Drosophila melanogaster 5-oxoprolyl-Lys-Arg-Leu-NH2 + NH3
-
 ?
H-Gln-Phe-Ala-OH
-
 Drosophila melanogaster 5-oxoprolyl-Phe-Ala-OH + NH3
-
 ?
H-Gln-Phe-Ala-OH isoDromeQC Drosophila melanogaster 5-oxoprolyl-Phe-Ala-OH + NH3
-
 ?
H-Gln-Tyr-Ala-OH
-
 Drosophila melanogaster 5-oxoprolyl-Tyr-Ala-OH + NH3
-
 ?
H-Gln-Tyr-Ala-OH isoDromeQC Drosophila melanogaster 5-oxoprolyl-Tyr-Ala-OH + NH3
-
 ?
H-Gln-Val-Ala-OH
-
 Drosophila melanogaster 5-oxoprolyl-Val-Ala-OH + NH3
-
 ?
H-Gln-Val-Ala-OH isoDromeQC Drosophila melanogaster 5-oxoprolyl-Val-Ala-OH + NH3
-
 ?
L-Gln-7-amido-4-methylcoumarin
-
 Drosophila melanogaster 5-oxoprolyl-4-methylcoumarin-7-amide + NH3
-
 ?
L-Gln-7-amido-4-methylcoumarin isoDromeQC Drosophila melanogaster 5-oxoprolyl-4-methylcoumarin-7-amide + NH3
-
 ?
L-glutaminyl-7-amido-4-methylcoumarin
-
 Drosophila melanogaster L-pyroglutamyl-7-amido-4-methylcoumarin + NH3
-
 ?

Synonyms

Synonyms Comment Organism
DromeQC
-
 Drosophila melanogaster
isoDromeQC
-
 Drosophila melanogaster

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1
-
 H-Gln-beta-naphthylamide 30°C, isoDromeQC Drosophila melanogaster
1.3
-
 H-Gln-beta-naphthylamide 30°C Drosophila melanogaster
2.09
-
 L-glutaminyl-7-amido-4-methylcoumarin 30°C, isoDromeQC Drosophila melanogaster
3.02
-
 H-Gln-Val-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
4.9
-
 H-Gln-Gly-OH 30°C, isoDromeQC Drosophila melanogaster
5.3
-
 H-Gln-Val-Ala-OH 30°C Drosophila melanogaster
6.9
-
 H-Gln-Glu-Tyr-Phe-NH2 30°C Drosophila melanogaster
7
-
 H-Gln-Gln-OH 30°C Drosophila melanogaster
7
-
 H-Gln-Lys-Arg-Leu-NH2 30°C Drosophila melanogaster
7
-
 L-glutaminyl-7-amido-4-methylcoumarin 30°C Drosophila melanogaster
7.4
-
 H-Gln-Gln-OH 30°C, isoDromeQC Drosophila melanogaster
9
-
 H-Gln-Gly-OH 30°C Drosophila melanogaster
11
-
 H-Gln-Glu-Ala-Phe-NH2 30°C, isoDromeQC Drosophila melanogaster
12.7
-
 H-Gln-Glu-Ala-Phe-NH2 30°C Drosophila melanogaster
14
-
 H-Gln-Asp-Glu-Leu-NH2 30°C Drosophila melanogaster
14
-
 H-Gln-Gly-Pro-OH 30°C, isoDromeQC Drosophila melanogaster
16
-
 H-Gln-Gly-Pro-OH 30°C Drosophila melanogaster
16
-
 H-Gln-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
16
-
 H-Gln-Phe-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
17
-
 H-Gln-Ala-OH 30°C Drosophila melanogaster
17.04
-
 H-Gln-Tyr-Ala-OH 30°C, isoDromeQC Drosophila melanogaster
22
-
 H-Gln-Phe-Ala-OH 30°C Drosophila melanogaster
38
-
 H-Gln-Glu-OH 30°C Drosophila melanogaster

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000097
-
 P150/03 pH 8, isoDromeQC Drosophila melanogaster
0.000101
-
 1-Methylimidazole pH 7, isoDromeQC Drosophila melanogaster
0.00094
-
 P150/03 pH 7 Drosophila melanogaster
0.00314
-
 P150/03 pH 8 Drosophila melanogaster
0.013
-
 1-Benzylimidazole pH 7 Drosophila melanogaster
0.017
-
 benzimidazole pH 7, isoDromeQC Drosophila melanogaster
0.019
-
 1-Benzylimidazole pH 8, isoDromeQC Drosophila melanogaster
0.036
-
 1-Methylimidazole pH 7 Drosophila melanogaster
0.0391
-
 N-omega-acetylhistamine pH 7 Drosophila melanogaster
0.048
-
 1-Benzylimidazole pH 8 Drosophila melanogaster
0.056
-
 cysteamine pH 8 Drosophila melanogaster
0.063
-
 N-dimethylcysteamine pH 8, isoDromeQC Drosophila melanogaster
0.073
-
 4-methylimidazole pH 8 Drosophila melanogaster
0.079
-
 N-dimethylcysteamine pH 8 Drosophila melanogaster
0.08
-
 N-dimethylcysteamine pH 7 Drosophila melanogaster
0.084
-
 N-omega-acetylhistamine pH 8 Drosophila melanogaster
0.093
-
 N-diethylcysteamine pH 8 Drosophila melanogaster
0.103
-
 1-Methylimidazole pH 8, isoDromeQC Drosophila melanogaster
0.109
-
 1-Methylimidazole pH 8 Drosophila melanogaster
0.114
-
 1-Benzylimidazole pH 7, isoDromeQC Drosophila melanogaster
0.14
-
 N-omega-acetylhistamine pH 8, isoDromeQC Drosophila melanogaster
0.145
-
 P150/03 pH 7, isoDromeQC Drosophila melanogaster
0.154
-
 cysteamine pH 7, isoDromeQC Drosophila melanogaster
0.205
-
 cysteamine pH 8, isoDromeQC Drosophila melanogaster
0.301
-
 cysteamine pH 7 Drosophila melanogaster
0.304
-
 imidazole pH 7 Drosophila melanogaster
0.364
-
 imidazole pH 8, isoDromeQC Drosophila melanogaster
0.405
-
 N-diethylcysteamine pH 8, isoDromeQC Drosophila melanogaster
0.549
-
 benzimidazole pH 7 Drosophila melanogaster
0.671
-
 imidazole pH 7, isoDromeQC Drosophila melanogaster
0.827
-
 N-omega-acetylhistamine pH 7, isoDromeQC Drosophila melanogaster
1.141
-
 imidazole pH 8 Drosophila melanogaster
1.145
-
 benzimidazole pH 8, isoDromeQC Drosophila melanogaster
2.188
-
 benzimidazole pH 8 Drosophila melanogaster