Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D248A | kcat/KM for Gln-2-naphthylamide is 136fold lower than wild-type value | Homo sapiens |
D248Q | kcat/KM for Gln-2-naphthylamide is 7123fold lower than wild-type value | Homo sapiens |
D305A | kcat/KM for Gln-2-naphthylamide is 1493fold lower than wild-type value | Homo sapiens |
D305E | kcat/KM for Gln-2-naphthylamide is 21000fold lower than wild-type value | Homo sapiens |
D305N | kcat/KM for Gln-2-naphthylamide is 772fold lower than wild-type value | Homo sapiens |
E201D | kcat/KM for Gln-2-naphthylamide is 68fold lower than wild-type value | Homo sapiens |
H319L | kcat/KM for Gln-2-naphthylamide is 15fold lower than wild-type value | Homo sapiens |
S160A | kcat/KM for Gln-2-naphthylamide is 3fold lower than wild-type value | Homo sapiens |
S160G | kcat/KM for Gln-2-naphthylamide is 68fold lower than wild-type value | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.058 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, wild-type enzyme | Homo sapiens | |
0.125 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D248A | Homo sapiens | |
0.161 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme H319L | Homo sapiens | |
0.174 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme S160A | Homo sapiens | |
0.254 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D305N | Homo sapiens | |
0.33 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D248Q | Homo sapiens | |
0.431 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D305E | Homo sapiens | |
0.615 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme S160G | Homo sapiens | |
0.736 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme E201D | Homo sapiens | |
1.1 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D305A | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
hanging-drop vapour-diffusion method, wild-type and mutant enzymes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gln-2-naphthylamide | - |
Homo sapiens | 2-oxoprolyl-2-naphthylamide + NH3 | - |
? | |
Gln-4-methylcoumarinylamide | - |
Homo sapiens | 2-oxoprolyl-4-methylcoumarinylamide + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutaminyl cyclase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D305E | Homo sapiens | |
0.0042 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D248Q | Homo sapiens | |
0.03 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D305N | Homo sapiens | |
0.068 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D305A | Homo sapiens | |
0.085 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme D248A | Homo sapiens | |
0.84 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme S160G | Homo sapiens | |
1 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme E201D | Homo sapiens | |
1 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme H319L | Homo sapiens | |
5.3 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, mutant enzyme S160A | Homo sapiens | |
5.4 | - |
Gln-2-naphthylamide | pH 8.0, 25°C, wild-type enzyme | Homo sapiens |