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Literature summary for 2.3.2.5 extracted from

  • Cynis, H.; Schilling, S.; Bodnar, M.; Hoffmann, T.; Heiser, U.; Saido, T.C.; Demuth, H.
    Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells (2006), Biochim. Biophys. Acta, 1764, 1618-1625.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea i.e. P150/03, complete inhibition at 0.01 mM Homo sapiens
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea i.e. P150/03, complete inhibition at 0.01 mM Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme is important during cellular maturation of L-pyroglutamyl-containing peptides ?
-
?
additional information Homo sapiens enzyme is important during cellular maturation of L-pyroglutamyl-containing peptides ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
beta-TC3 cell
-
Mus musculus
-
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
L-363 cell plasma cell leukemia cell line Homo sapiens
-
L-929 cell
-
Mus musculus
-
RAW-264.7 cell
-
Mus musculus
-
U-343 cell glioma cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Gln(3)-amyloid-beta peptide 3-42
-
Mus musculus L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + NH3
-
?
L-Gln(3)-amyloid-beta peptide 3-42
-
Homo sapiens L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + NH3
-
?
L-Gln-2-naphthylamide reaction in cell supernatant is exclusively enzyme-catalyzed Mus musculus L-pyroglutamyl-2-naphthylamide + NH3
-
?
L-Gln-2-naphthylamide reaction in cell supernatant is exclusively enzyme-catalyzed Homo sapiens L-pyroglutamyl-2-naphthylamide + NH3
-
?
L-Glu(3)-amyloid-beta peptide 3-42
-
Mus musculus L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + H2O
-
?
L-Glu(3)-amyloid-beta peptide 3-42
-
Homo sapiens L-pyroglutamyl(3)-amyloid-beta peptide 3-42 + H2O
-
?
additional information enzyme is important during cellular maturation of L-pyroglutamyl-containing peptides Mus musculus ?
-
?
additional information enzyme is important during cellular maturation of L-pyroglutamyl-containing peptides Homo sapiens ?
-
?