Literature summary for 2.3.2.31 extracted from

Duda, D.; Olszewski, J.; Schuermann, J.; Kurinov, I.; Miller, D.; Nourse, A.; Alpi, A.; Schulman, B.
Structure of HHARI, a RING-IBR-RING ubiquitin ligase Autoinhibition of an Ariadne-family E3 and insights into ligation mechanism (2013), Structure, 21, 1030-1041 .

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Protein Variants

Protein Variants	Comment	Organism
H359A	catalytic loop mutant	Homo sapiens
N358A	catalytic loop mutant	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[E2 ubiquitin-conjugating enzyme UBCH7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine	Homo sapiens	overall reaction	[E2 ubiquitin-conjugating enzyme UBCH7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y4X5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is auto-inhibited	Homo sapiens	?	-	?
[E2 ubiquitin-conjugating enzyme UBCH7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine	overall reaction	Homo sapiens	[E2 ubiquitin-conjugating enzyme UBCH7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine	-	?

Subunits

Subunits	Comment	Organism
?	x * 45000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
HHARI	-	Homo sapiens
RBR E3	-	Homo sapiens

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Release 2023.1 (January 2023)