Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14139 | isoform Ube4A | - |
Synonyms | Comment | Organism |
---|---|---|
Ube4A | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Ube4A is required for complete assembly of specific DNA damage repair factors at double-strand break sites and proper internal organization of double-strand break-associated protein foci. UBE4A's recruitment to sites of DNA damage is dependent on primary E3 ligases in the DNA damage repair and promotes enhancement and sustainment of K48- and K63-linked ubiquitin chains at these sites. This step is required for timely recruitment of the RAP80 and BRCA1 proteins and proper organization of RAP80- and BRCA1-associated protein complexes at double-strand break sites. The pathway is required for optimal end-resection at double-strand breaks, and its abrogation leads to up-regulation of the highly mutagenic alternative end-joining repair at the expense of error-free homologous recombination repair | Homo sapiens |