Activating Compound | Comment | Organism | Structure |
---|---|---|---|
PINK1 | Parkin activation as an E3 ubiquitin ligase is regulated by PTEN-induced putative kinase 1 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T and HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A46P | the mutant shows barely detectable autoubiquitination activity compared to the wild type | Homo sapiens |
C431S | the mutant shows barely detectable autoubiquitination activity compared to the wild type | Homo sapiens |
K27N | the mutant shows barely detectable autoubiquitination activity compared to the wild type | Homo sapiens |
K48A | the mutant has higher autoubiquitination activity than the wild type | Homo sapiens |
R33Q | the mutant shows barely detectable autoubiquitination activity compared to the wild type | Homo sapiens |
R42P | the mutant has higher autoubiquitination activity than the wild type | Homo sapiens |
T240R | the mutant shows barely detectable autoubiquitination activity compared to the wild type | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Parkin E3 ligase has autoubiquitination activity | ? | - |
? | |
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine | Homo sapiens | - |
[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Parkin E3 ligase has autoubiquitination activity | Homo sapiens | ? | - |
? | |
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine | - |
Homo sapiens | [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
E3 ubiquitin ligase | - |
Homo sapiens |
Parkin | - |
Homo sapiens |