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Literature summary for 2.3.2.27 extracted from

  • Fiesel, F.; Moussaud-Lamodiere, E.; Ando, M.; Springer, W.
    A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently (2014), J. Cell Sci., 127, 3488-3504.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens O60260
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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HeLa cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Parkin
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 Homo sapiens

General Information

General Information Comment Organism
metabolism the cognate E2 co-enzymes of E3 enzyme Parkin regulate the activation, translocation and enzymatic functions of Parkin during mitochondrial quality control. UBE2D family members and UBE2L3 redundantly charge the RING-HECT hybrid ligase Parkin with ubiquitin, resulting in its initial activation and translocation to mitochondria. UBE2N primarily mediates the proper clustering of mitochondria, a prerequisite for degradation. Depletion of UBE2R1 results in enhanced Parkin translocation and clustering upon mitochondrial uncoupling Homo sapiens