Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.27 extracted from

  • Lee, S.J.; Choi, J.Y.; Sung, Y.M.; Park, H.; Rhim, H.; Kang, S.
    E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme (2001), FEBS Lett., 503, 61-64.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construcution of N-terminal deletion mutants. The N-terminal region of RNF2, including the RING finger domain, is essential for the protein-protein interaction with E2 enzymes Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99496
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ubiquitinyl-[Hip2]-L-cysteine + [acceptor protein]-L-lysine
-
Homo sapiens [Hip2]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine isoform RNF2 interacts with E2 protein Hip2, i.e. Huntingtin-interacting protein-2, and with Ubc4, UbcH5. RNF2 shows ubiquitin transferase E3 activity in the presence of Hip2 ?

Synonyms

Synonyms Comment Organism
RNF2
-
Homo sapiens