Literature summary for 2.3.2.27 extracted from

Wang, P.; Wu, Y.; Li, Y.; Zheng, J.; Tang, J.
A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1 (2013), Cell. Signal., 25, 2320-2333.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NXI6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RNF186]-L-lysine	BNip1 is a Bcl-2 family protein	Homo sapiens	[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-(ubiquitin)n-[RNF186]-L-lysine	isoform RNF186 undergoes RING-dependent self-ubiquitination	?
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [BNip1]-L-lysine	BNip1 is a Bcl-2 family protein	Homo sapiens	[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[BNip1]-L-lysine	BNip1 is polyubiquitinated by isoform RNF186 through K29 and K63 linkage in vivo. This modification promotes BNip1 transportation to mitochondria but has no influence on its protein level	?

Synonyms

Synonyms	Comment	Organism
Ring finger protein 186	-	Homo sapiens
RNF186	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	RING finger E3 ligase RNF186 participates in the process of endoplasmic reticulum stress-mediated apoptosis. Overexpression of RNF186 stimulates upregulation of endoplasmic reticulum sensor proteins and rapid transmission of endoplasmic reticulum Ca2+ in Hela cells, while RNF186 knockdown leads to a moderate degree of resistance to endoplasmic reticulum stress. The half-life of substrate RNF186 is prolonged under endoplasmic reticulum stress, and the ubiquitination of BNip1 is greatly enhanced when endoplasmic reticulum stress occurs. Knockdown of BNip1 attenuates the stress signals at endoplasmic reticulum induced by RNF186	Homo sapiens

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Release 2023.1 (January 2023)