Literature summary for 2.3.2.27 extracted from

Saha, A.; Lewis, S.; Kleiger, G.; Kuhlman, B.; Deshaies, R.J.
Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate (2011), Mol. Cell, 42, 75-83.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[CDC34]-S-ubiquitinyl-L-cysteine + [SCF]-L-lysine	acceptor protein SCF consists of the cullin Cul1, the RING subunit Rbx1/Roc1/Hrt1, the adaptor protein Skp1, and an F-box protein such as Skp2 or TrCP that binds substrates	Homo sapiens	[CDC34]-L-cysteine + [SCF]-N6-ubiquitinyl-L-lysine	the I44A mutation in ubiquitin profoundly inhibits its ability to serve as a donor for ubiquitin chain initiation or elongation, but can be rescued by compensatory mutations in the E2 Cdc34	?

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Release 2023.1 (January 2023)