Cloned (Comment) | Organism |
---|---|
expression in HEK-293T cell and HBL human melanoma cell | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | MGRN1 isoforms containing exon 12 are targeted to the nucleus by the melanocortin receptors | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60921 | isoform MGRN1 | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform GRN1 interacts with melanocortin receptor and decreases melanocortin receptors MC1R and MC4R signaling to cAMP. Inhibition of MC1R signaling by MGRN1 is not dependent on receptor down-regulation as a result of internalization or degradation. Receptor ubiquitylation is not a requisite for inhibition of signaling | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mahogunin ring finger-1 | - |
Homo sapiens |
MGRN1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | human melanoma cells express four MGRN isoforms | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform GRN1 interacts with melanocortin receptor and decreases melanocortin receptors MC1R and MC4R signaling to cAMP. Inhibition of MC1R signaling by MGRN1 is not dependent on receptor down-regulation as a result of internalization or degradation. Receptor ubiquitylation is not a requisite for inhibition of signaling | Homo sapiens |