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Literature summary for 2.3.2.27 extracted from

  • Perez-Oliva, A.B.; Olivares, C.; Jimenez-Cervantes, C.; Garcia-Borron, J.C.
    Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas (2009), J. Biol. Chem., 284, 31714-31725.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell and HBL human melanoma cell Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus MGRN1 isoforms containing exon 12 are targeted to the nucleus by the melanocortin receptors Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O60921 isoform MGRN1
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform GRN1 interacts with melanocortin receptor and decreases melanocortin receptors MC1R and MC4R signaling to cAMP. Inhibition of MC1R signaling by MGRN1 is not dependent on receptor down-regulation as a result of internalization or degradation. Receptor ubiquitylation is not a requisite for inhibition of signaling Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
mahogunin ring finger-1
-
Homo sapiens
MGRN1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens human melanoma cells express four MGRN isoforms additional information

General Information

General Information Comment Organism
physiological function isoform GRN1 interacts with melanocortin receptor and decreases melanocortin receptors MC1R and MC4R signaling to cAMP. Inhibition of MC1R signaling by MGRN1 is not dependent on receptor down-regulation as a result of internalization or degradation. Receptor ubiquitylation is not a requisite for inhibition of signaling Homo sapiens