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BRENDA support

Literature summary for 2.3.2.27 extracted from

  • Chin, L.S.; Vavalle, J.P.; Li, L.
    Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation (2002), J. Biol. Chem., 277, 35071-35079.
    View publication on PubMed
Search for more literature for 2.3.2.27

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
membrane membrane-associated Rattus norvegicus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
113800
-
 x * 113800, calculated Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q8CJB9 isoform BRE1B
-

Source Tissue

Source Tissue Comment Organism Textmining
brain abundantly expressed Rattus norvegicus
-
heart abundantly expressed Rattus norvegicus
-
kidney abundantly expressed Rattus norvegicus
-
liver abundantly expressed Rattus norvegicus
-
testis abundantly expressed Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[BRE1B-ubiquitin-carrier protein UbcH8]-S-ubiquitinyl-L-cysteine + [syntaxin1]-L-lysine isoform BRE1B binds and recruits the brain-enriched E2 ubiquitin-conjugating enzyme UbcH8 to syntaxin 1 and facilitates the ubiquitination and proteasome-dependent degradation of syntaxin1 Rattus norvegicus [BRE1B-ubiquitin-carrier protein UbcH8]-L-cysteine + [syntaxin1]-N6-ubiquitinyl-L-lysine
-
 ?

Subunits

Subunits Comment Organism
? x * 113800, calculated Rattus norvegicus

Synonyms

Synonyms Comment Organism
BRE1B
-
 Rattus norvegicus