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Literature summary for 2.3.2.2 extracted from

  • Corti, A.; Duarte, T.L.; Giommarelli, C.; De Tata, V.; Paolicchi, A.; Jones, G.D.; Pompella, A.
    Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells (2009), Mutat. Res., 669, 112-121.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transfection of human melanoma cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information in transfected melanoma cells, higher levels of GGT activity are associated with higher levels of background DNA damage and oxidized bases. GGT-over-expressing cells also present with a markedly higher glucose uptake, potentially leading to higher metabolic rate and oxidative DNA damage. When GGT-over-expressing cells are incubated in the presence of GGT substrates and a source of catalytic iron, increased levels of DNA damage and oxidized bases are observed Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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