Any feedback?
Literature summary for 2.3.2.2 extracted from
- Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model (2008), Nutr. Cancer, 60, 518-525.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| L-glutamine | enhanced enzyme activity in jejunal mucosa | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-glutamine | inhibition of enzyme activity in tumor tissue | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P07314 | Sprague-Dawley rats, female | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Rattus norvegicus | - |
| jejunal mucosa | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 12 | - |
measured in jejunal mucosa in DMBA-treated rats wiht tumor | Rattus norvegicus |
| 15 | - |
measured in jejunal mucosa in normal rats | Rattus norvegicus |
| 16 | - |
measured in jejunal mucosa in DMBA-treated rats without tumor | Rattus norvegicus |
| 18 | - |
measured in jejunal mucosa after treatment with dietary glutamine in DMBA-treated rats with tumor | Rattus norvegicus |
| 20 | - |
measured in jejunal mucosa after treatment with dietary glutamine in normal rats | Rattus norvegicus |
| 25 | - |
measured in jejunal mucosa after treatment with dietary glutamine in DMBA-treated rats without tumor | Rattus norvegicus |
| 45 | - |
measured in tumor tissue after treatment with dietary glutamine | Rattus norvegicus |
| 80 | - |
measured in tumor tissue | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-gamma-glutamyl-3-carboxy-4-nitroanilide + H2O | assay at pH 8 | Rattus norvegicus | 3-carboxy-4-nitroaniline + L-glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gamma-glutamyltranspeptidase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
