Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(L-gamma-glutamylamino)-2-nitrobenzoic acid | enzyme from human tissues, not serum | Homo sapiens | |
glycine | - |
Homo sapiens | |
glycine | - |
Rattus norvegicus | |
glycylglycine | - |
Homo sapiens | |
glycylglycine | - |
Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular | - |
Rattus norvegicus | - |
- |
membrane | extrinsic to plasma membrane | Homo sapiens | 16020 | - |
membrane | extrinsic to plasma membrane | Rattus norvegicus | 16020 | - |
membrane | extrinsic to plasma membrane | Oryctolagus cuniculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
86000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + an amino acid | Homo sapiens | involved in 5-L-glutamyl cycle of glutathione metabolism | L-cysteinylglycine + a 5-L-glutamyl-amino acid | - |
? | |
glutathione + an amino acid | Oryctolagus cuniculus | involved in 5-L-glutamyl cycle of glutathione metabolism | L-cysteinylglycine + a 5-L-glutamyl-amino acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | rich in carbohydrates | Homo sapiens |
glycoprotein | rich in carbohydrates | Rattus norvegicus |
glycoprotein | rich in carbohydrates | Oryctolagus cuniculus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | active site on small subunit | Homo sapiens | |
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | active site on small subunit | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | serum | Homo sapiens | - |
duodenum | - |
Homo sapiens | - |
duodenum | - |
Rattus norvegicus | - |
duodenum | - |
Oryctolagus cuniculus | - |
epithelium | proximal tubular | Rattus norvegicus | - |
intestine | - |
Homo sapiens | - |
intestine | - |
Rattus norvegicus | - |
intestine | - |
Oryctolagus cuniculus | - |
kidney | luminal membrane of proximal tubules | Homo sapiens | - |
kidney | luminal membrane of proximal tubules | Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Oryctolagus cuniculus | - |
lymphoid cell | - |
Homo sapiens | - |
pancreas | - |
Rattus norvegicus | - |
pancreas | - |
Oryctolagus cuniculus | - |
pancreas | acinar cells, apical part | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5-L-glutamyl)-peptide + acceptor + H+ | donor: 5-L-Glu-3-sulfonic-4-nitroanilide | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: 5-L-Glu-3-sulfonic-4-nitroanilide | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: 5-L-Glu-3-sulfonic-4-nitroanilide | Oryctolagus cuniculus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: GSH S-substituted derivatives | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: GSH S-substituted derivatives | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: GSH S-substituted derivatives | Oryctolagus cuniculus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is 5-L-Glu-4-nitroanilide | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is 5-L-Glu-4-nitroanilide | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is 5-L-Glu-4-nitroanilide | Oryctolagus cuniculus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptors are amino acids or dipeptides | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptors are amino acids or dipeptides | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptors are amino acids or dipeptides | Oryctolagus cuniculus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: 5-L-Glu-naphthylamide | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: 5-L-Glu-naphthylamide | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor: 5-L-Glu-naphthylamide | Oryctolagus cuniculus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptor specificity, overview | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptor specificity, overview | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptor specificity, overview | Oryctolagus cuniculus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is GSH | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is GSH | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is GSH | Oryctolagus cuniculus | peptide + 5-L-glutamyl amino acid | - |
? | |
5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine | - |
Homo sapiens | 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline | - |
? | |
5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine | - |
Rattus norvegicus | 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline | - |
? | |
5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine | - |
Oryctolagus cuniculus | 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline | - |
? | |
5-L-glutamyl-4-nitroanilide + glycylglycine | best acceptor | Homo sapiens | 4-nitroaniline + 5-L-glutamylglycylglycine | - |
? | |
5-L-glutamyl-4-nitroanilide + glycylglycine | best acceptor | Rattus norvegicus | 4-nitroaniline + 5-L-glutamylglycylglycine | - |
? | |
5-L-glutamyl-4-nitroanilide + glycylglycine | best acceptor | Oryctolagus cuniculus | 4-nitroaniline + 5-L-glutamylglycylglycine | - |
? | |
5-L-glutamyl-4-nitroanilide + L-cystine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamyl-L-cystine | - |
? | |
5-L-glutamyl-4-nitroanilide + L-cystine | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamyl-L-cystine | - |
? | |
5-L-glutamyl-4-nitroanilide + L-cystine | - |
Oryctolagus cuniculus | 4-nitroaniline + 5-L-glutamyl-L-cystine | - |
? | |
glutathione + acceptor | - |
Homo sapiens | cysteinylglycine + 5-L-glutamyl-acceptor | - |
? | |
glutathione + acceptor | - |
Rattus norvegicus | cysteinylglycine + 5-L-glutamyl-acceptor | - |
? | |
glutathione + acceptor | - |
Oryctolagus cuniculus | cysteinylglycine + 5-L-glutamyl-acceptor | - |
? | |
glutathione + an amino acid | involved in 5-L-glutamyl cycle of glutathione metabolism | Homo sapiens | L-cysteinylglycine + a 5-L-glutamyl-amino acid | - |
? | |
glutathione + an amino acid | involved in 5-L-glutamyl cycle of glutathione metabolism | Oryctolagus cuniculus | L-cysteinylglycine + a 5-L-glutamyl-amino acid | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the active site resides on the small subunit | Homo sapiens |
More | the active site resides on the small subunit | Rattus norvegicus |