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Literature summary for 2.3.2.13 extracted from

  • Wilhelmus, M.M.; de Jager, M.; Smit, A.B.; van der Loo, R.J.; Drukarch, B.
    Catalytically active tissue transglutaminase colocalises with Abeta pathology in Alzheimers disease mouse models (2016), Sci. Rep., 6, 20569.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.13

Inhibitors

Inhibitors Comment Organism Structure
Z-DON-Val-Pro-Leu-OMe irreversible inhibitor Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[amyloid-beta]-L-glutamine + alkylamine Mus musculus
-
 [amyloid-beta]-N5-alkyl-L-glutamine + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[amyloid-beta]-L-glutamine + alkylamine
-
 Mus musculus [amyloid-beta]-N5-alkyl-L-glutamine + NH3
-
 ?
[T26 protein]-L-glutamine + 5-(biotinamido)-pentylamine
-
 Mus musculus [T26 protein]-N5-pentyl-L-glutamine + biotin
-
 ?

Synonyms

Synonyms Comment Organism
tissue transglutaminase
-
 Mus musculus
tTG
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is associated with amyloid-beta deposits and lesion-associated astrocytes in Alzheimer's disease Mus musculus