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Literature summary for 2.3.2.13 extracted from

  • Badarau, E.; Wang, Z.; Rathbone, D.L.; Costanzi, A.; Thibault, T.; Murdoch, C.E.; El Alaoui, S.; Bartkeviciute, M.; Griffin, M.
    Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions (2015), Chem. Biol., 22, 1347-1361.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2-tert-butoxy-2-oxoethyl)(dimethyl)sulfonium
-
Homo sapiens
(2-[[(1R)-3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-1-carboxy-3-oxopropyl]amino]-2-oxoethyl)(dimethyl)sulfanium bromide
-
Homo sapiens
(2-[[4-(methoxycarbonyl)benzyl]oxy]-2-oxoethyl)(dimethyl)sulfonium
-
Homo sapiens
(2-[[6-(methoxycarbonyl)naphthalen-2-yl]methoxy]-2-oxoethyl)(dimethyl)sulfonium
-
Homo sapiens
(naphthalen-2-yl)methyl 4-(N-acryloylglycyl)piperazine-1-carboxylate
-
Homo sapiens
(naphthalen-2-yl)methyl 4-[N-(bromoacetyl)glycyl]piperazine-1-carboxylate
-
Homo sapiens
1-(ethenylsulfonyl)tricyclo[3.3.1.13,7]decane
-
Homo sapiens
1-(tricyclo[3.3.1.13,7]dec-1-yl)prop-2-en-1-one
-
Homo sapiens
2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl prop-2-enoate
-
Homo sapiens
2-([2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl]sulfanyl)-1,3,4,5-tetramethyl-1H-imidazol-3-ium bromide
-
Homo sapiens
2-bromo-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
-
Homo sapiens
2-chloro-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
-
Homo sapiens
benzyl 4-[3-(acryloylamino)-2-oxopropanoyl]piperazine-1-carboxylate
-
Homo sapiens
benzyl 4-[3-[(ethenylsulfonyl)amino]-2-oxopropanoyl]piperazine-1-carboxylate
-
Homo sapiens
dimethyl[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]sulfonium
-
Homo sapiens
dimethyl[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)ethyl]sulfonium
-
Homo sapiens
dimethyl[2-oxo-2-[2-(tricyclo[3.3.1.13,7]dec-1-yl)ethoxy]ethyl]sulfonium
-
Homo sapiens
methyl 4-[(acryloyloxy)methyl]benzoate
-
Homo sapiens
methyl 4-[[(bromoacetyl)oxy]methyl]benzoate
-
Homo sapiens
methyl 6-[(acryloyloxy)methyl]naphthalene-2-carboxylate
-
Homo sapiens
methyl 6-[[(bromoacetyl)oxy]methyl]naphthalene-2-carboxylate
-
Homo sapiens
methyl 6-[[(chloroacetyl)oxy]methyl]naphthalene-2-carboxylate
-
Homo sapiens
N-(2-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-2-oxoethyl)prop-2-enamide
-
Homo sapiens
tricyclo[3.3.1.13,7]dec-1-ylmethyl bromoacetate
-
Homo sapiens
tricyclo[3.3.1.13,7]dec-1-ylmethyl prop-2-enoate
-
Homo sapiens
[2-[(2-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-2-oxoethyl)amino]-2-oxoethyl](dimethyl)sulfanium
-
Homo sapiens
[2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl](diethyl)sulfanium bromide
-
Homo sapiens
[2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl](dimethyl)sulfanium bromide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
Homo sapiens
-
NIH-3T3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cbz-Gln-Gly + alkylamine
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TG2
-
Homo sapiens
transglutaminase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000021
-
at pH 7.1, temperature not specified in the publication Homo sapiens methyl 4-[[(bromoacetyl)oxy]methyl]benzoate
0.0000039
-
at pH 7.1, temperature not specified in the publication Homo sapiens 2-bromo-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
0.0000061
-
at pH 7.1, temperature not specified in the publication Homo sapiens N-(2-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-2-oxoethyl)prop-2-enamide
0.00000629
-
at pH 7.1, temperature not specified in the publication Homo sapiens tricyclo[3.3.1.13,7]dec-1-ylmethyl bromoacetate
0.00000665
-
at pH 7.1, temperature not specified in the publication Homo sapiens methyl 6-[[(chloroacetyl)oxy]methyl]naphthalene-2-carboxylate
0.00000875
-
at pH 7.1, temperature not specified in the publication Homo sapiens 2-chloro-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
0.000015
-
at pH 7.1, temperature not specified in the publication Homo sapiens methyl 6-[[(bromoacetyl)oxy]methyl]naphthalene-2-carboxylate
0.000029
-
at pH 7.1, temperature not specified in the publication Homo sapiens (naphthalen-2-yl)methyl 4-[N-(bromoacetyl)glycyl]piperazine-1-carboxylate
0.000125
-
at pH 7.1, temperature not specified in the publication Homo sapiens 1-(tricyclo[3.3.1.13,7]dec-1-yl)prop-2-en-1-one
0.000273
-
at pH 7.1, temperature not specified in the publication Homo sapiens (2-tert-butoxy-2-oxoethyl)(dimethyl)sulfonium
0.00038
-
at pH 7.1, temperature not specified in the publication Homo sapiens [2-[(2-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-2-oxoethyl)amino]-2-oxoethyl](dimethyl)sulfanium
0.00044
-
at pH 7.1, temperature not specified in the publication Homo sapiens (naphthalen-2-yl)methyl 4-(N-acryloylglycyl)piperazine-1-carboxylate
0.0007
-
at pH 7.1, temperature not specified in the publication Homo sapiens (2-[[(1R)-3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-1-carboxy-3-oxopropyl]amino]-2-oxoethyl)(dimethyl)sulfanium bromide
0.000775
-
at pH 7.1, temperature not specified in the publication Homo sapiens dimethyl[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)ethyl]sulfonium
0.000875
-
at pH 7.1, temperature not specified in the publication Homo sapiens 1-(ethenylsulfonyl)tricyclo[3.3.1.13,7]decane
0.000889
-
at pH 7.1, temperature not specified in the publication Homo sapiens dimethyl[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]sulfonium
0.0009
-
at pH 7.1, temperature not specified in the publication Homo sapiens 2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl prop-2-enoate
0.00107
-
at pH 7.1, temperature not specified in the publication Homo sapiens (naphthalen-2-yl)methyl 4-(N-acryloylglycyl)piperazine-1-carboxylate
0.0014
-
at pH 7.1, temperature not specified in the publication Homo sapiens [2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl](dimethyl)sulfanium bromide
0.0015
-
at pH 7.1, temperature not specified in the publication Homo sapiens (2-[[6-(methoxycarbonyl)naphthalen-2-yl]methoxy]-2-oxoethyl)(dimethyl)sulfonium
0.001625
-
at pH 7.1, temperature not specified in the publication Homo sapiens tricyclo[3.3.1.13,7]dec-1-ylmethyl prop-2-enoate
0.001725
-
at pH 7.1, temperature not specified in the publication Homo sapiens benzyl 4-[3-[(ethenylsulfonyl)amino]-2-oxopropanoyl]piperazine-1-carboxylate
0.00185
-
at pH 7.1, temperature not specified in the publication Homo sapiens [2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl](diethyl)sulfanium bromide
0.0021
-
at pH 7.1, temperature not specified in the publication Homo sapiens methyl 6-[(acryloyloxy)methyl]naphthalene-2-carboxylate
0.00315
-
at pH 7.1, temperature not specified in the publication Homo sapiens dimethyl[2-oxo-2-[2-(tricyclo[3.3.1.13,7]dec-1-yl)ethoxy]ethyl]sulfonium
0.0033
-
at pH 7.1, temperature not specified in the publication Homo sapiens (2-[[4-(methoxycarbonyl)benzyl]oxy]-2-oxoethyl)(dimethyl)sulfonium
0.005925
-
at pH 7.1, temperature not specified in the publication Homo sapiens benzyl 4-[3-(acryloylamino)-2-oxopropanoyl]piperazine-1-carboxylate
0.0063
-
at pH 7.1, temperature not specified in the publication Homo sapiens methyl 4-[(acryloyloxy)methyl]benzoate
0.1
-
at pH 7.1, temperature not specified in the publication Homo sapiens 2-([2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl]sulfanyl)-1,3,4,5-tetramethyl-1H-imidazol-3-ium bromide