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Literature summary for 2.3.2.13 extracted from

  • Salter, N.W.; Ande, S.R.; Nguyen, H.K.; Nyomba, B.L.; Mishra, S.
    Functional characterization of naturally occurring transglutaminase 2 mutants implicated in early-onset type 2 diabetes (2012), J. Mol. Endocrinol., 48, 203-216.
    View publication on PubMed
Search for more literature for 2.3.2.13

Cloned(Commentary)

Cloned (Comment) Organism
expressed in INS-1E cells Mus musculus

Protein Variants

Protein Variants Comment Organism
C277A the mutant lacks transamidation function Mus musculus
I331N the mutant is associated with early-onset type 2 diabetes, has no GTP-binding ability and shows 32% of wild type activity Mus musculus
M330R the mutant is associated with early-onset type 2 diabetes, has very weak GTP-binding ability and shows 20% of wild type activity Mus musculus
N333S the mutant is associated with early-onset type 2 diabetes, has elevated GTP-binding ability and shows 7% of wild type activity Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
TG2
-
 Mus musculus
transglutaminase 2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction transglutaminase 2 (TG2) mutations are associated with diabetes type 2. Lack of TG2 reduces glucose-stimulated insulin secretion from the pancreatic islets Mus musculus