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Literature summary for 2.3.2.13 extracted from

  • Facchiano, F.; DArcangelo, D.; Lentini, A.; Rossi, S.; Senatore, C.; Pannellini, T.; Tabolacci, C.; Facchiano, A.M.; Facchiano, A.; Beninati, S.
    Tissue transglutaminase activity protects from cutaneous melanoma metastatic dissemination: an in vivo study (2013), Amino Acids, 44, 53-61.
    View publication on PubMed
Search for more literature for 2.3.2.13

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
89000
-
 x * 89000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B16-F10 cell
-
 Mus musculus
-
HaCaT cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-kDa heat shock protein-bound gamma-glutamine + methylamine
-
 Homo sapiens 10-kDa heat shock protein N5-methylglutamine + NH3
-
 ?
60-kDa heat shock protein-bound gamma-glutamine + methylamine
-
 Homo sapiens 60-kDa heat shock protein N5-methylglutamine + NH3
-
 ?
actin-bound gamma-glutamine + methylamine
-
 Homo sapiens actin N5-methylglutamine + NH3
-
 ?
alpha-actin-bound gamma-glutamine + methylamine
-
 Homo sapiens alpha-actin N5-methylglutamine + NH3
-
 ?
clathrin heavy chain-bound gamma-glutamine + methylamine
-
 Homo sapiens clathrin heavy chain N5-methylglutamine + NH3
-
 ?
cytoskeletal 1 keratin type II-bound gamma-glutamine + methylamine
-
 Homo sapiens cytoskeletal 1 keratin type II N5-methylglutamine + NH3
-
 ?
cytoskeletal 2 epidermal keratin type II-bound gamma-glutamine + methylamine
-
 Homo sapiens cytoskeletal 2 epidermal keratin type II N5-methylglutamine + NH3
-
 ?
cytoskeletal 5 keratin type II-bound gamma-glutamine + methylamine
-
 Homo sapiens cytoskeletal 5 keratin type II N5-methylglutamine + NH3
-
 ?
cytoskeletal 6A keratin type II-bound gamma-glutamine + methylamine
-
 Homo sapiens cytoskeletal 6A keratin type II N5-methylglutamine + NH3
-
 ?
filamin A-bound gamma-glutamine + methylamine
-
 Homo sapiens filamin A N5-methylglutamine + NH3
-
 ?
galectin-3-bound gamma-glutamine + methylamine
-
 Homo sapiens galectin-3 N5-methylglutamine + NH3
-
 ?
H2A histone type 1-bound gamma-glutamine + methylamine
-
 Homo sapiens H2A histone type 1 N5-methylglutamine + NH3
-
 ?
H2B histone type 1-bound gamma-glutamine + methylamine
-
 Homo sapiens H2B histone type 1 N5-methylglutamine + NH3
-
 ?
H4 histone -bound gamma-glutamine + methylamine
-
 Homo sapiens H4 histone N5-methylglutamine + NH3
-
 ?
nucleophosmin-bound gamma-glutamine + methylamine
-
 Homo sapiens nucleophosmin N5-methylglutamine + NH3
-
 ?
protein-bound gamma-glutamine + methylamine
-
 Mus musculus protein N5-methylglutamine + NH3
-
 ?
spectrin alpha-bound gamma-glutamine + methylamine
-
 Homo sapiens spectrin alpha N5-methylglutamine + NH3
-
 ?
vimentin-bound gamma-glutamine + methylamine
-
 Homo sapiens vimentin N5-methylglutamine + NH3
-
 ?

Subunits

Subunits Comment Organism
? x * 89000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
TG-2
-
 Mus musculus
TG-2
-
 Homo sapiens
TGase-2
-
 Mus musculus
TGase-2
-
 Homo sapiens
tissue transglutaminase
-
 Mus musculus
tissue transglutaminase
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus enzyme expression is significantly lower in melanoma cells than in control keratinocytes down
Homo sapiens enzyme expression is significantly lower in melanoma cells than in control keratinocytes down

General Information

General Information Comment Organism
physiological function tissue transglutaminase activity protects from cutaneous melanoma metastatic dissemination. The number of melanoma lung foci is more markedly reduced by enzyme overexpression than the metastatic size Mus musculus
physiological function tissue transglutaminase activity protects from cutaneous melanoma metastatic dissemination. The number of melanoma lung foci is more markedly reduced by enzyme overexpression than the metastatic size Homo sapiens