Literature summary for 2.3.2.13 extracted from

Zhang, Z.; Xing, J.; Ma, L.; Gong, R.; Chin, Y.E.; Zhuang, S.
Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3 (2009), J. Biol. Chem., 284, 3345-3353.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Monodansylcadaverine	treatment of proximal renal tublule cells with inhibitor monodansylcadaverine or siRNA results in decreased proliferation accompanied by activation of signal transducer and activator of transcription, Akt and Stat-3. Treatment with monodansylcadaverine or TGase-1 siRNA decreases Stat-3 but not Akt phosphorylation. TGase-1 interacts with Janus-activated kinase JAK2, and this interaction is inhibited by monodansylcadaverine	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9JLF6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
renal proximal tubule	cells express isoform TGase-1, but not TGase-2, -5, and -7	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	treatment of proximal renal tublule cells with inhibitor monodansylcadaverine or siRNA results in decreased proliferation accompanied by activation of signal transducer and activator of transcription, Akt and Stat-3. Treatment with monodansylcadaverine or TGase-1 siRNA decreases Stat-3 but not Akt phosphorylation. Janus-activated kinase JAK2 mediates phosphorylation of Stat-3, and knockdown of either JAK2 or Stat-3 by siRNA decreases cell proliferation. Inhibition of TGase-1 decreases phosphorylation of Stat-3 but not JAK2. JAK2 is indispensable for TGase-1 to induce Stat-3 phosphorylation and TGase-1 potentiates JAK2-induced Stat-3 phosphorylation. Inhibition of TGase-1 and the JAK2-Stat-3 signaling pathway decreases the transcriptional activity of Stat-3 and expression of the Stat-3-targeted genes, cyclin D1 and cyclin E. TGase-1 interacts with JAK2, and this interaction is inhibited by monodansylcadaverine	Mus musculus

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Release 2023.1 (January 2023)