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Literature summary for 2.3.2.13 extracted from

  • Biagi, F.; Campanella, J.; Laforenza, U.; Gastaldi, G.; Tritto, S.; Grazioli, M.; Villanacci, V.; Corazza, G.R.
    Transglutaminase 2 in the enterocytes is coeliac specific and gluten dependent (2006), Dig. Liver Dis., 38, 652-658.
    View publication on PubMed

Application

Application Comment Organism
medicine epithelial distribution of tissue transglutaminase is specific for coeliac disease rather than due to a non-specific mucosal inflammation. Epithelial distribution of enzyme is gluten dependent Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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coeliac patients and healthy indivuduals
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Source Tissue

Source Tissue Comment Organism Textmining
enterocyte isoform transglutaminase 2, both in patients with coeliac disease and controls. Enzyme is localized to subepithelial layer, lamina propria, and the pericryptal connective issue of all samples. It also binds to surface enterocytes of most untreated, but of few treated, coeliac patients, and shows no epithelial distribution in controls Homo sapiens
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