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Literature summary for 2.3.2.13 extracted from

  • Griffin, M.; Casadio, R.; Bergamini, C.M.
    Transglutaminases: Nature's biological glues (2002), Biochem. J., 368, 377-396.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens P21980
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Mammalia
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8 distinct transglutaminase isoenzymes have been identified on the genomic level, 6 have been isolated and characterized: factor XIII, type 1 or keratinocyte transglutaminase, type 2 or tissue transglutaminase, type 3 or epidermal transglutaminase, type 4 or prostate transglutaminase and type 5 transglutaminase
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein-bound gamma-glutamine + alkylamine
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Rattus norvegicus protein N5-alkylglutamine + NH3
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protein-bound gamma-glutamine + alkylamine
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Homo sapiens protein N5-alkylglutamine + NH3
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protein-bound gamma-glutamine + alkylamine endogenous substrates: cellular proteins e.g. aldolase, glyceraldehyde-3-phosphate dehydrogenase, phosphorylase kinase, crystallins, gluthathione S-transferase, actin, myosin, troponin, beta-tubulin, tau, Rho A, histone, alpha-oxoglutarate dehydrogenase, cytochromes, erythrocyte band III, CD38, acetylcholine esterase, collagen, fibronectin, fibrinogen, vitronectin, osteopontin, nidogen, laminin, LTBP-1, osteonectin, osteocalcin, substance P, phospholipase A2, midkine, exogenous substrates: wheat gliadin, whey proteins, soy proteins, pea legumin, Candida albicans surface proteins, HIV envelope glycoproteins gp120 and gp41, HIV aspartyl proteinase, hepatitis C virus core protein Mammalia protein N5-alkylglutamine + NH3
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