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Literature summary for 2.3.2.13 extracted from

  • Dadabay, C.Y.; Pike, L.J.
    Purification and characterization of a cytosolic transglutaminase from a cultured human tumour-cell line (1989), Biochem. J., 264, 679-685.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
GTP inhibition of tissue transglutaminase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
soluble
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein-bound gamma-glutamine + alkylamine Homo sapiens involved in a wide variety of cellular processes, including growth, differentiation, stabilization of cytoskeleton protein N5-alkylglutamine + NH3
-
?
protein-bound gamma-glutamine + alkylamine Homo sapiens last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules protein N5-alkylglutamine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cytosolic tissue transglutaminase, DE52, heparin-agarose, casein-agarose Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell epidermal carcinoma cell line Homo sapiens
-
epidermis stratum corneum Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.156
-
tissue transglutaminase Homo sapiens

Storage Stability

Storage Stability Organism
4°C, 50 mM Tris, pH 7.5, 1 mM EDTA/0.5 mM DTT, up to 2 weeks, no loss of activity Homo sapiens
dilute enzyme solutions are unstable to storage at 4°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein-bound gamma-glutamine + alkylamine involved in a wide variety of cellular processes, including growth, differentiation, stabilization of cytoskeleton Homo sapiens protein N5-alkylglutamine + NH3
-
?
protein-bound gamma-glutamine + alkylamine last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
?
putrescine + N,N'-dimethylcasein
-
Homo sapiens ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4
-
at least 20 min stable, pH 9.0 Homo sapiens
37
-
t1/2: 1-2 min, pH 9.0 Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
9
-
t1/2: 1-2 min stable at 37°C, at least 20 min stable at 4°C Homo sapiens