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Literature summary for 2.3.2.12 extracted from

  • Bernal-Cabas, M.; Ayala, J.A.; Raivio, T.L.
    The Cpx envelope stress response modifies peptidoglycan cross-linking via the L,D-transpeptidase LdtD and the novel protein YgaU (2015), J. Bacteriol., 197, 603-614.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
67000
-
x * 67000, calculated from amino acid sequence Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2 Escherichia coli the enzyme synthesizes diaminopimelic acid (DAP)-DAP cross-links by the removal of the fourth D-alanine residue of an acyl donor tetrapeptide stem and the attachment of the remaining meso-DAP residue to the meso-DAP residue of a second acyl acceptor peptide tRNA1 + peptidyl(aminoacyl-tRNA2)
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2 the enzyme synthesizes diaminopimelic acid (DAP)-DAP cross-links by the removal of the fourth D-alanine residue of an acyl donor tetrapeptide stem and the attachment of the remaining meso-DAP residue to the meso-DAP residue of a second acyl acceptor peptide Escherichia coli tRNA1 + peptidyl(aminoacyl-tRNA2)
-
?

Subunits

Subunits Comment Organism
? x * 67000, calculated from amino acid sequence Escherichia coli

Synonyms

Synonyms Comment Organism
L,D-transpeptidase
-
Escherichia coli
LdtD
-
Escherichia coli

Expression

Organism Comment Expression
Escherichia coli the enzyme is upregulated in response to Cpx envelope stress response-inducing conditions up