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Literature summary for 2.3.2.12 extracted from

  • Cerna, J.; Rychlik, I.
    Phenylboric acids - A new group of peptidyl transferase inhibitors (1980), FEBS Lett., 119, 342-348.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
m-nitrophenylboric acid more potent inhibitor than phenylboric acid Escherichia coli
phenylboric acid
-
Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
Escherichia coli 5840
-

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'(3')-O-(N-formylmethionyl)-adenosine-5'-phosphate + CACCA-Phe
-
Escherichia coli ?
-
?
AcPhe-tRNA + puromycin
-
Escherichia coli tRNA + AcPhe-puromycin
-
?
CACCA-AcLeu + puromycin fragment reaction Escherichia coli CACCA + AcLeu-puromycin
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.46
-
m-nitrophenylboric acid
-
Escherichia coli
0.52
-
phenylboric acid
-
Escherichia coli