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Literature summary for 2.3.2.12 extracted from

  • Cerna, J.; Rychlik, I.; Lichtenthaler, F.W.
    The effect of the aminoacyl-4-aminohexosyl-cytosine group of antibiotics on ribosomal peptidyl transferase (1973), FEBS Lett., 30, 147-150.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Amicetin complete inhibition with AcPhe-tRNA as donor, with polylysyl-tRNA as donor less active Escherichia coli
Bamicetin complete inhibition with AcPhe-tRNA as donor, with polylysyl-tRNA as donor less active Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
Escherichia coli 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 Escherichia coli
-
tRNA1 + peptidyl-amino-tRNA2
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
B cells
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AcPhe-tRNA + puromycin reaction only in the presence of 70S ribosomes and the appropriate mRNA Escherichia coli tRNA + AcPhe-puromycin
-
?
CACCA-AcLeu + puromycin fragment reaction Escherichia coli CACCA + AcLeu-puromycin
-
?
peptidyl-tRNA1 + alpha-aminoacyl-tRNA2
-
Escherichia coli tRNA1 + peptidyl-amino-tRNA2
-
?
polylysyl-tRNA + puromycin reaction only in the presence of 70S ribosomes and the appropriate mRNA Escherichia coli tRNA + polylysyl-puromycin
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
enzyme assay Escherichia coli