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Literature summary for 2.3.2.10 extracted from

  • Fonvielle, M.; Chemama, M.; Villet, R.; Lecerf, M.; Bouhss, A.; Valery, J.M.; Etheve-Quelquejeu, M.; Arthur, M.
    Aminoacyl-tRNA recognition by the FemXWv transferase for bacterial cell wall synthesis (2009), Nucleic Acids Res., 37, 1589-1601.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine Fem transferases are considered as attractive targets for the development of novel antibiotics active against multi-resistant bacteria Weissella viridescens

Inhibitors

Inhibitors Comment Organism Structure
oxa-helixAla
-
Weissella viridescens
oxa-helixGly
-
Weissella viridescens
oxa-helixSer
-
Weissella viridescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Weissella viridescens FemXWv transferase adds the first residue of the L-Ala-L-Ser-L-Ala side chain onto the nucleotide precursor UDP-MurNAc-pentadepsipeptide ?
-
?

Organism

Organism UniProt Comment Textmining
Weissella viridescens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Weissella viridescens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
relative activity of FemXWv for the transfer of L-Ala from helixAla to UDP-MurNAc-pentapeptide 100% Weissella viridescens
additional information
-
relative activity of FemXWv for the transfer of L-Ala from helixGly to UDP-MurNAc-pentapeptide 2.9% Weissella viridescens
additional information
-
relative activity of FemXWv for the transfer of L-Ala from helixSer to UDP-MurNAc-pentapeptide 31% Weissella viridescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information FemXWv transferase adds the first residue of the L-Ala-L-Ser-L-Ala side chain onto the nucleotide precursor UDP-MurNAc-pentadepsipeptide Weissella viridescens ?
-
?

Synonyms

Synonyms Comment Organism
FemXWv transferase
-
Weissella viridescens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
inhibition assay Weissella viridescens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
inhibition assay Weissella viridescens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
-
Weissella viridescens oxa-helixAla
0.015
-
-
Weissella viridescens oxa-helixSer
0.067
-
-
Weissella viridescens oxa-helixGly