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Literature summary for 2.3.1.B43 extracted from

  • Wang, Y.; Zhu, Y.; Xing, S.; Ma, P.; Lin, D.
    SIRT5 prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3 (2015), Cell Stress Chaperones, 20, 805-810.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [forkhead box O3]-N6-acetyl-L-lysine Homo sapiens the enzyme deacetylates FOXO3 at K271 and K290 nicotinamide + [forkhead box O3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [forkhead box O3]-N6-acetyl-L-lysine the enzyme deacetylates FOXO3 at K271 and K290 Homo sapiens nicotinamide + [forkhead box O3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
NAD+-dependent protein deacetylase
-
 Homo sapiens
nicotinamide adenine dinucleotide-dependent protein deacetylase
-
 Homo sapiens
SIRT5
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens cigarette smoke extract induces the enzyme up

General Information

General Information Comment Organism
physiological function the enzyme prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3 Homo sapiens