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Literature summary for 2.3.1.B43 extracted from

  • Lu, W.; Zuo, Y.; Feng, Y.; Zhang, M.
    SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer (2014), Tumour Biol., 35, 10699-10705.
    View publication on PubMed
Search for more literature for 2.3.1.B43

Application

Application Comment Organism
medicine SIRT5 may serve as a potential prognostic factor and drug target for intervention in non-small cell lung cancer. SIRT5 is overexpressed in human non-small cell lung cancer cells, high expression of SIRT5 predicts poor survival. SIRT5 knockdown makes lung cancer cells more sensitive to drug (cis-diamminedichloroplatinum, 5-fluorouracil or bleomycin) treatment in vitro and in vivo. Nrf2, which is a core transcription factor for lung cancer growth and drug resistance, is a target of SIRT5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
non-small cell lung cancer cell SIRT5 is overexpressed in human non-small cell lung cancer cells, high expression of SIRT5 predicts poor survival Homo sapiens
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Synonyms

Synonyms Comment Organism
SIRT5
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction SIRT5 knockdown represses lung cancer cell growth and transformation in vitro and in vivo. SIRT5 knockdown makes lung cancer cells more sensitive to drug (cis-diamminedichloroplatinum, 5-fluorouracil or bleomycin) treatment in vitro and in vivo. Nrf2, which is a core transcription factor for lung cancer growth and drug resistance, is a target of SIRT5 Homo sapiens
metabolism SIRT5 is a protein responsible for growth and drug resistance in human non-small cell lung cancer cells Homo sapiens