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Literature summary for 2.3.1.B43 extracted from

  • Gertz, M.; Nguyen, G.T.; Fischer, F.; Suenkel, B.; Schlicker, C.; Fränzel, B.; Tomaschewski, J.; Aladini, F.; Becker, C.; Wolters, D.; Steegborn, C.
    A molecular mechanism for direct sirtuin activation by resveratrol (2012), PLoS One, 7, e49761.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Activating Compound

Activating Compound Comment Organism Structure
piceatannol stimulates EC50: 0.07 mM Homo sapiens
resveratrol 0.2 mM resveratrol can stimulate the Sirt5 deacetylase activity against the fluorophore-modified peptide substrate Fluor-de-Lys Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of Sirt5 in complex with fluor-de-Lys peptide and resveratrol and crystal structure of Sirt5 in complex with fluor-de-Lys peptide and piceatannol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fisetin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
SIRT5
-
 Homo sapiens