Literature summary for 2.3.1.B43 extracted from

Buler, M.; Aatsinki, S.M.; Izzi, V.; Uusimaa, J.; Hakkola, J.
SIRT5 is under the control of PGC-1alpha and AMPK and is involved in regulation of mitochondrial energy metabolism (2014), FASEB J., 28, 3225-3237.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8K2C6	-	-

Synonyms

Synonyms	Comment	Organism
SIRT5	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	overexpression of AMP-activated protein kinase (AMPK) in mouse hepatocytes downregulates expression of SIRT5 mRNA by 58%. The antidiabetes drug metformin (1 mM), an established AMPK activator, reduces the mouse SIRT5 protein level by 44% in cultured hepatocytes and by 31% in liver in vivo (300 mg/kg, 7 d)	down

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in regulation of mitochondrial energy metabolism	Mus musculus
physiological function	SIRT5 overexpression increases ATP synthesis and oxygen consumption in HepG2 cells, but does not affect mitochondrial biogenesis	Mus musculus

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Release 2023.1 (January 2023)