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Literature summary for 2.3.1.B41 extracted from

  • Tasselli, L.; Xi, Y.; Zheng, W.; Tennen, R.I.; Odrowaz, Z.; Simeoni, F.; Li, W.; Chua, K.F.
    SIRT6 deacetylates H3K18Ac at pericentric chromatin to prevent mitotic errors and cellular senescence (2016), Nat. Struct. Mol. Biol., 23, 434-440.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Protein Variants

Protein Variants Comment Organism
H133Y inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine18 Homo sapiens
-
 nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine18
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inactivation in cells leads to histone H3-Lys18 hyperacetylation and aberrant accumulation of pericentric transcripts Homo sapiens
physiological function the enzyme deacetylates histone H3-Lys18 at pericentric chromatin to prevent mitotic errors and cellular senescence Homo sapiens