Literature summary for 2.3.1.B41 extracted from

Maksin-Matveev, A.; Kanfi, Y.; Hochhauser, E.; Isak, A.; Cohen, H.Y.; Shainberg, A.
Sirtuin 6 protects the heart from hypoxic damage (2015), Exp. Cell Res., 330, 81-90.

Search for more literature for 2.3.1.B41

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P59941	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte	-	Mus musculus	-
heart	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Mus musculus
sirtuin 6	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	dependent on	Mus musculus

General Information

General Information	Comment	Organism
physiological function	sirtuin 6 protects the heart from hypoxic damage. The protective mechanism of sirtuin 6 overexpression includes the activation of pAMPKalpha pathway, the increased proteinlevel of B-cell lymphoma 2, the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells, the decrease of reactive oxygen species, and the reduction in the protein level of phosphor-protein kinase B during hypoxia	Mus musculus

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Release 2023.1 (January 2023)