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Literature summary for 2.3.1.B41 extracted from

  • Cea, M.; Cagnetta, A.; Adamia, S.; Acharya, C.; Tai, Y.T.; Fulciniti, M.; Ohguchi, H.; Munshi, A.; Acharya, P.; Bhasin, M.K.; Zhong, L.; Carrasco, R.; Monacelli, F.; Ballestrero, A.; Richardson, P.; Gobbi, M.; Lemoli, R.M.; Munshi, N.; Hideshima, T.; Nencioni, A.; Chauhan, D.; Anderson, K.C.
    Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells (2016), Blood, 127, 1138-1150.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
x * 42000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [histone H3]-N6-palmitoyl-L-lysine9 Homo sapiens
-
nicotinamide + [histone H3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
multiple myeloma cell high expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-palmitoyl-L-lysine9
-
Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
?

Subunits

Subunits Comment Organism
? x * 42000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
protein-long-chain fatty-acyl-lysine deacylase
-
Homo sapiens
Sir2A
-
Homo sapiens
SIRT6
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Homo sapiens

General Information

General Information Comment Organism
malfunction inhibiting SIRT6 activity enhances anti-multiple myeloma activity of doxorubicin in vivo Homo sapiens
physiological function SIRT6 downregulates the expression of mitogen-activated protein kinase pathway genes, signaling, and proliferation. In addition, inactivation of ERK2/p90RSK signaling triggered by high SIRT6 levels increases DNA repair via Chk1 and confers resistance to DNA damage Homo sapiens