Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SIRT6 | - |
Homo sapiens |
sirtuin 6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | SIRT6 deficiency causes major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells | Homo sapiens |
physiological function | SIRT6 is a critical modulator of retinal function, likely through its effects on chromatin | Homo sapiens |