Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.B41 extracted from

  • Gil, R.; Barth, S.; Kanfi, Y.; Cohen, H.Y.
    SIRT6 exhibits nucleosome-dependent deacetylase activity (2013), Nucleic Acids Res., 41, 8537-8545.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome SIRT6 activity is nucleosome dependent, and suggest that its binding to the nucleosome might convert it into an active structure Homo sapiens 786
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine Homo sapiens
-
 nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine Homo sapiens
-
 nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H3]-N6-acetyl-L-lysine the enzyme deacetylates histones H3 and H4 when they are packaged as nucleosomes, but not as free histones Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine
-
 Homo sapiens nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine the enzyme deacetylates histones H3 and H4 when they are packaged as nucleosomes, but not as free histones Homo sapiens nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?