Literature summary for 2.3.1.B41 extracted from

Cardinale, A.; de Stefano, M.C.; Mollinari, C.; Racaniello, M.; Garaci, E.; Merlo, D.
Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response (2015), Neurochem. Res., 40, 59-69.

Search for more literature for 2.3.1.B41

Cloned(Commentary)

Cloned (Comment)	Organism
SIRT6 overexpression in terminally differentiated cortical and hippocampal neurons, mediated by a neuron-specific recombinant adeno-associated virus, downregulates cell viability under oxidative stress condition	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P59941	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	highly expressed in cortical and hippocampal regions and enriched in the synaptosomal membrane fraction	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Mus musculus
sirtuin 6	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	in cortical and hippocampal neurons SIRT6 is downregulated during maturation in vitro, reaching the lowest expression at 11 days in vitro	down

General Information

General Information	Comment	Organism
metabolism	SIRT6 may play a role in synaptic function and neuronal maturation and it may be implicated in the regulation of neuronal survival	Mus musculus

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Release 2023.1 (January 2023)