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Literature summary for 2.3.1.B40 extracted from
- Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8 (2013), J. Am. Chem. Soc., 135, 14339-14348.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Micromonospora echinospora |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 8 malonyl-CoA + NADPH + H+ | Micromonospora echinospora | - |
8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2 | the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin | ? |  |
| additional information | Micromonospora echinospora | a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Micromonospora echinospora | Q8KNG1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 8 malonyl-CoA + NADPH + H+ | - |
Micromonospora echinospora | 8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2 | the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin | ? | |
| additional information | a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction | Micromonospora echinospora | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CalE8 | - |
Micromonospora echinospora |
| enediyne polyketide synthase | - |
Micromonospora echinospora |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | polyketide is an authentic product of CalE8 and may be a key precursor to the enediyne core of calicheamicin | Micromonospora echinospora |
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