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Literature summary for 2.3.1.B38 extracted from

  • Dulcey, C.E.; Dekimpe, V.; Fauvelle, D.A.; Milot, S.; Groleau, M.C.; Doucet, N.; Rahme, L.G.; Lepine, F.; Deziel, E.
    The end of an old hypothesis: the Pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids (2013), Chem. Biol., 20, 1481-1491.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa A0A0H2Z7A3 and A0A0H2Z7K6 A0A0H2Z7A3 i.e. subunit PqsC, and A0A0H2Z7K6, i.e. subunit PqsB
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Pseudomonas aeruginosa UCBPP-PA14 A0A0H2Z7A3 and A0A0H2Z7K6 A0A0H2Z7A3 i.e. subunit PqsC, and A0A0H2Z7K6, i.e. subunit PqsB
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Synonyms

Synonyms Comment Organism
PqsB
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 Pseudomonas aeruginosa
PqsC
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 Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function 4-hydroxy-2-alkylquinoline biosynthesis, which requires the PqsABCD enzymes, proceeds by a two-step pathway: PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-coenzyme A and malonyl-coenzyme A, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of 3,4-dihydroxy-2-heptylquinoline. PqsB is tightly associated with PqsC and required for the second step. None of the pqsA-, pqsB-, pqsC-, and pqs- mutants produces measurable amounts of 4-hydroxy-2-alkylquinolines, and PqsB and PqsC have to be present simultaneously to transform the intermediate into 4-hydroxy-2-heptylquinoline Pseudomonas aeruginosa