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Literature summary for 2.3.1.B27 extracted from

  • Marsh, V.L.; Peak-Chew, S.Y., Bell, S.D.
    Sir2 and the acetyltransferase, Pat, regulate the archaeal chromatin protein, Alba (2005), J. Biol. Chem., 280, 21122-21128.
    View publication on PubMed
Search for more literature for 2.3.1.B27

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli as a C-terminally hexahistidine-tagged protein Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 Saccharolobus solfataricus the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
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 ?
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 Saccharolobus solfataricus P2 the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
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 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q97V23
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Saccharolobus solfataricus P2 Q97V23
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-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation Saccharolobus solfataricus CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the enzyme specifically acetylates protein Alba1 (SSO0962) on L-lysine 16 Saccharolobus solfataricus CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
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 ?
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation Saccharolobus solfataricus P2 CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
-
 ?
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 the enzyme specifically acetylates protein Alba1 (SSO0962) on L-lysine 16 Saccharolobus solfataricus P2 CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
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 ?

Synonyms

Synonyms Comment Organism
SSO2813 locus name Saccharolobus solfataricus
ssPat
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 Saccharolobus solfataricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
65
-
 assay at Saccharolobus solfataricus
70 90
-
 Saccharolobus solfataricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Saccharolobus solfataricus

General Information

General Information Comment Organism
physiological function the DNA binding affinity of the chromatin protein Alba1 is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA Saccharolobus solfataricus