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Literature summary for 2.3.1.97 extracted from

  • Lakshmikuttyamma, A.; Selvakumar, P.; Tuchek, J.; Sharma, R.
    Myristoyltransferase and calcineurin: novel molecular therapeutic target for epilepsy (2008), Prog. Neurobiol., 84, 77-84.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for drug design in the treatment of epilepsy Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens strong interaction of NMT2 with caspase-3 with a probable major role in the cellular regulation of NMT2, caspase-3 interaction with NMT2 is stronger than with NMT1. The cellular regulation of NMT1 and NMT2 is mediated by two different signaling molecules, m-calpain and caspase, respectively, overview. Protein-protein interaction of NMT forms and p53 ?
-
?
tetradecanoyl-CoA + glycyl-pp60c-Src Homo sapiens
-
CoA + N-tetradecanoyl-glycyl-pp60c-Src
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes NMT1 and NMT2
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information strong interaction of NMT2 with caspase-3 with a probable major role in the cellular regulation of NMT2, caspase-3 interaction with NMT2 is stronger than with NMT1. The cellular regulation of NMT1 and NMT2 is mediated by two different signaling molecules, m-calpain and caspase, respectively, overview. Protein-protein interaction of NMT forms and p53 Homo sapiens ?
-
?
tetradecanoyl-CoA + glycyl-pp60c-Src
-
Homo sapiens CoA + N-tetradecanoyl-glycyl-pp60c-Src
-
?
tetradecanoyl-CoA + glycyl-pp60c-Src i.e. myristoyl-CoA Homo sapiens CoA + N-tetradecanoyl-glycyl-pp60c-Src
-
?

Synonyms

Synonyms Comment Organism
myristoyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction NMT plays a role in epilepsy Homo sapiens
physiological function N-myristoylation is a co-translational, irreversible addition of a fatty acyl moiety to the amino terminus of many eukaryotic cellular proteins. These myristoylated proteins in the cell have diverse biological functions such as signal transduction, cellular transformation and oncogensis Homo sapiens