Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for drug design in the treatment of epilepsy | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | strong interaction of NMT2 with caspase-3 with a probable major role in the cellular regulation of NMT2, caspase-3 interaction with NMT2 is stronger than with NMT1. The cellular regulation of NMT1 and NMT2 is mediated by two different signaling molecules, m-calpain and caspase, respectively, overview. Protein-protein interaction of NMT forms and p53 | ? | - |
? | |
tetradecanoyl-CoA + glycyl-pp60c-Src | Homo sapiens | - |
CoA + N-tetradecanoyl-glycyl-pp60c-Src | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes NMT1 and NMT2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | strong interaction of NMT2 with caspase-3 with a probable major role in the cellular regulation of NMT2, caspase-3 interaction with NMT2 is stronger than with NMT1. The cellular regulation of NMT1 and NMT2 is mediated by two different signaling molecules, m-calpain and caspase, respectively, overview. Protein-protein interaction of NMT forms and p53 | Homo sapiens | ? | - |
? | |
tetradecanoyl-CoA + glycyl-pp60c-Src | - |
Homo sapiens | CoA + N-tetradecanoyl-glycyl-pp60c-Src | - |
? | |
tetradecanoyl-CoA + glycyl-pp60c-Src | i.e. myristoyl-CoA | Homo sapiens | CoA + N-tetradecanoyl-glycyl-pp60c-Src | - |
? |
Synonyms | Comment | Organism |
---|---|---|
myristoyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | NMT plays a role in epilepsy | Homo sapiens |
physiological function | N-myristoylation is a co-translational, irreversible addition of a fatty acyl moiety to the amino terminus of many eukaryotic cellular proteins. These myristoylated proteins in the cell have diverse biological functions such as signal transduction, cellular transformation and oncogensis | Homo sapiens |