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Literature summary for 2.3.1.97 extracted from

  • Shrivastav, A.; Varma, S.; Lawman, Z.; Yang, S.H.; Ritchie, S.A.; Bonham, K.; Singh, S.M.; Saxena, A.; Sharma, R.K.
    Requirement of N-myristoyltransferase 1 in the development of monocytic lineage (2008), J. Immunol., 180, 1019-1028.
    View publication on PubMed
Search for more literature for 2.3.1.97

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout leads to defective myelopoesis, NMT1 knockout in U-937 cells leads to defective monocytic differentiation. Suppressed macrophage colony forming units are observed in M-CSF-stimulated bone marrow cells from heterozygous Nmt1-deficient mice, while homozygous Nmt1-deficient mouse embryonic stem cells show a drastic reduction of macrophages when stimulated to differentiate by M-CSF Mus musculus
additional information NMT1 knockout in U-937 cells by siRNA leads to defective monocytic differentiation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
heat shock cognate protein 70 involved in NMT1 regulation, overview Homo sapiens
heat shock cognate protein 70 involved in NMT1 regulation, overview; involved in NMT1 regulation, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol predominantly Homo sapiens 5829
-
cytosol predominantly Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis ?
-
 ?
additional information Mus musculus isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis ?
-
 ?
additional information Mus musculus isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis ?
-
 ?
tetradecanoyl-CoA + glycyl-pp60cSrc Mus musculus i.e. myristoyl-CoA CoA + N-tetradecanoyl-glycyl-pp60cSrc
-
 ?
tetradecanoyl-CoA + glycyl-pp60c Src Mus musculus i.e. myristoyl-CoA CoA + N-tetradecanoyl-glycyl-pp60c Src
-
 ?
tetradecanoyl-CoA + glycyl-pp60c-Src Homo sapiens i.e. myristoyl-CoA CoA + N-tetradecanoyl-glycyl-pp60c-Src
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme NMT1
-
Mus musculus O70310 NMT1; isozyme NMT1
-
Mus musculus O70311 NMT2; isozyme NMT2
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow cell
-
 Mus musculus
-
embryonic stem cell
-
 Mus musculus
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis Homo sapiens ?
-
 ?
additional information isozyme NMT1 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis Mus musculus ?
-
 ?
additional information isozyme NMT2 catalyzes myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis Mus musculus ?
-
 ?
tetradecanoyl-CoA + glycyl-pp60cSrc i.e. myristoyl-CoA Mus musculus CoA + N-tetradecanoyl-glycyl-pp60cSrc
-
 ?
tetradecanoyl-CoA + glycyl-pp60c Src i.e. myristoyl-CoA Mus musculus CoA + N-tetradecanoyl-glycyl-pp60c Src
-
 ?
tetradecanoyl-CoA + glycyl-pp60c-Src i.e. myristoyl-CoA Homo sapiens CoA + N-tetradecanoyl-glycyl-pp60c-Src
-
 ?

Synonyms

Synonyms Comment Organism
N-myristoyltransferase 1
-
 Homo sapiens
N-myristoyltransferase 1
-
 Mus musculus
NMT
-
 Homo sapiens
NMT
-
 Mus musculus
NMT1
-
 Homo sapiens
NMT1
-
 Mus musculus
NMT2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockout leads to defective myelopoesis Mus musculus
physiological function NMT1 is essential for the differentiation of U937 cells Homo sapiens
physiological function NMT1 is required in the development of monocytic lineage and essential for the early development of mouse embryo Mus musculus