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Literature summary for 2.3.1.97 extracted from

  • Ebara, S.; Naito, H.; Nakazawa, K.; Ishii, F.; Nakamura, M.
    FTR1335 is a novel synthetic inhibitor of Candida albicans N-myristoyltransferase with fungicidal activity (2005), Biol. Pharm. Bull., 28, 591-595.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
(1R,3S)-N-{2-[(cyclopeanthylcarbonyl)amino]-benzothiazol-6-yl}-3-[(2-naphthylmethyl) amino] cyclohexanecarboxamide competitive with the substrate peptide and non-competitive with myristoyl-CoA. IC50: 0.49 nM Candida albicans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000000362
-
GLTISKLFRR-NH2
-
Candida albicans
0.00000283
-
myristoyl-CoA
-
Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans P30418
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myristoyl-CoA + GLTISKLFRR-NH2
-
Candida albicans ?
-
?

Synonyms

Synonyms Comment Organism
CaNMT
-
Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000049
-
competitive with the substrate peptide and non-competitive with myristoyl-CoA. IC50: 0.49 nM Candida albicans (1R,3S)-N-{2-[(cyclopeanthylcarbonyl)amino]-benzothiazol-6-yl}-3-[(2-naphthylmethyl) amino] cyclohexanecarboxamide