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Literature summary for 2.3.1.97 extracted from

  • Price, H.P.; Menon, M.R.; Panethymitaki, C.; Goulding, D.; McKean, P.G.; Smith, D.F.
    Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites (2003), J. Biol. Chem., 278, 7206-7214.
    View publication on PubMed
Search for more literature for 2.3.1.97

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Leishmania major 5737
-
membrane
-
 Leishmania major 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myristoyl-CoA + glycylpeptide Trypanosoma brucei the enzyme is essential for both life cycle stages of Trypanosoma brucei N-myristoylglycylpeptide + CoA
-
 ?
myristoyl-CoA + glycylpeptide Leishmania major the enzyme is essential for viability in Leishmania, constitutively expressed in all parasite stages N-myristoylglycylpeptide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major Q9GPZ4
-
-
Trypanosoma brucei
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania major
-
bloodstream form
-
 Trypanosoma brucei
-
metacyclic form
-
 Leishmania major
-
procyclic form
-
 Trypanosoma brucei
-
promastigote
-
 Leishmania major
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myristoyl-CoA + glycylpeptide the enzyme is essential for both life cycle stages of Trypanosoma brucei Trypanosoma brucei N-myristoylglycylpeptide + CoA
-
 ?
myristoyl-CoA + glycylpeptide the enzyme is essential for viability in Leishmania, constitutively expressed in all parasite stages Leishmania major N-myristoylglycylpeptide + CoA
-
 ?

Synonyms

Synonyms Comment Organism
myristoyl-CoA:protein N-myristoyltransferase
-
 Trypanosoma brucei
myristoyl-CoA:protein N-myristoyltransferase
-
 Leishmania major
NMT
-
 Trypanosoma brucei
NMT
-
 Leishmania major

pI Value

Organism Comment pI Value Maximum pI Value
Leishmania major
-
-
 6.1