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Literature summary for 2.3.1.97 extracted from

  • Lu, T.; Li, Q.; Katoh, A.; Hernandez, J.; Duffin, K.; Jackson-Machelski, E.; Knoll, L.J.; Gokel, G.W.; Gordon, J.I.
    The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Polar probes of the enzyme's myristoyl-CoA recognition site (1994), J. Biol. Chem., 269, 5346-5357.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myristoyl-CoA + glycylpeptide Saccharomyces cerevisiae enzyme is essential for vegetative growth N-myristoylglycylpeptide + CoA
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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recombinant Nmt1p from Escherichia coli
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Reaction

Reaction Comment Organism Reaction ID
tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein] ordered bi bi mechanism Saccharomyces cerevisiae
tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein] peptide binding site Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myristoyl-CoA + glycylpeptide substrate specificity Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
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?
myristoyl-CoA + glycylpeptide myristoyl-CoA can be replaced by CoA-derivatives of hydroxytetradecanoic acids, azidoaromatic analogues of myristic acid, omega-nitrocarboxylic acids, halogen- and haloaromatic analogues of myristic acid and, with low activity, by dicarboxylic fatty acids Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
?
myristoyl-CoA + glycylpeptide stereochemical requirements Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
?
myristoyl-CoA + glycylpeptide specific for Gly at N-terminus Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
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?
myristoyl-CoA + glycylpeptide enzyme is essential for vegetative growth Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
?
myristoyl-CoA + Pr55gag-precursor-derived octapeptide peptide substrate is derived from human immunodeficiency virus Saccharomyces cerevisiae N-myristoylated Pr55gag-precursor-derived peptide + CoA
-
?

Synonyms

Synonyms Comment Organism
Nmt1p
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Saccharomyces cerevisiae