Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.94 extracted from

  • Khosla, C.; Tang, Y.; Chen, A.Y.; Schnarr, N.A.; Cane, D.E.
    Structure and mechanism of the 6-deoxyerythronolide B synthase (2007), Annu. Rev. Biochem., 76, 195-221.
    View publication on PubMed
Search for more literature for 2.3.1.94

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression in Streptomyces coelicolor and Escherichia coli Saccharopolyspora erythraea

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ Saccharopolyspora erythraea
-
 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharopolyspora erythraea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
-
 Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Subunits

Subunits Comment Organism
oligomer the polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain, as a minimal requirement for chain extension, each module contains a set of three functional domains, a ketosynthase, an acyltransferae, and an acyl carrier protein Saccharopolyspora erythraea

Synonyms

Synonyms Comment Organism
6-deoxyerythronolide B synthase
-
 Saccharopolyspora erythraea
DEBS
-
 Saccharopolyspora erythraea
PKS
-
 Saccharopolyspora erythraea
polyketide synthase
-
 Saccharopolyspora erythraea