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Literature summary for 2.3.1.87 extracted from

  • Pozdeyev, N.; Taylor, C.; Haque, R.; Chaurasia, S.S.; Visser, A.; Thazyeen, A.; Du, Y.; Fu, H.; Weller, J.; Klein, D.C.; Iuvone, P.M.
    Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells (2006), J. Neurosci., 26, 9153-9161.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
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additional information exposing chickens to light in the middle of the night increased the apparent Km of AANAT for tryptamine by about 10fold. The Km began to increase within 5 min of exposure to light and reached a maximum at about 30 min Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000 100000 gel filtration Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein AANAT in dark-adapted retina is bound to 14-3-3 protein. This interaction is regulated by light and phosphorylation. Phosphorylation of AANAT in darkness promotes the association with 14-3-3, which decreases the Km of the enzyme for substrate and protects the enzyme from dephosphorylation and degradation. Light exposure results in dephosphorylation of AANAT and dissociation from the complex with 14-3-3 proteins, thereby increasing the Km of the enzyme. Dissociation of the complex leads to subsequent proteasomal proteolysis of AANAT Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
retina photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells Gallus gallus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + tryptamine
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Gallus gallus CoA + N-acetyltryptamine
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