Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-bromo-N-[2-(5-fluoro-1-benzothien-3-yl)ethyl]acetamide | IC50: 0.00039 mM | Homo sapiens | |
bromoacetyltryptamine | IC50: 0.0014 mM | Homo sapiens | |
methyl 3-[2-[(bromoacetyl)amino]ethyl]-1-benzothiophene-5-carboxylate | IC50: 0.00225 mM | Homo sapiens | |
N-[2-(2-benzyl-5-methoxy-benzofuran-3-yl)ethyl]iodoacetamide | IC50: 0.0087 mM | Homo sapiens | |
N-[2-(2-phenyl-benzo [b]thiophen-3-yl)ethyl]bromoacetamide | IC50: 0.001 mM | Homo sapiens | |
N-[2-(3-ethyl-7-methoxy-napht-1-yl)ethyl]iodoacetamide | IC50: 0.0006 mM | Homo sapiens | |
N-[2-(5-bromo-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | IC50: 0.00378 mM | Homo sapiens | |
N-[2-(5-chloro-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | IC50: 0.00018 mM | Homo sapiens | |
N-[2-(5-ethyl-1-benzothien-3-yl)ethyl]-2-iodoacetamide | IC50: 0.002 mM | Homo sapiens | |
N-[2-(5-ethyl-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | IC50: 0.00071 mM | Homo sapiens | |
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]bromoacetamide | IC50: 0.0056 mM | Homo sapiens | |
N-[2-(5-hydroxy-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | IC50: 0.00018 mM | Homo sapiens | |
N-[2-(7-ethyl-1,2,3,4-tetrahydronapht-1-yl)ethyl]iodooacetamide | IC50: above 0.1 mM | Homo sapiens | |
N-[2-(7-ethyl-napht-1-yl)ethyl]-bromoacetamide | IC50: 0.00177 mM | Homo sapiens | |
N-[2-(7-hydroxy-naphth-1-yl)ethyl]bromoacetamide | IC50: 0.00072 mM | Homo sapiens | |
N-[2-(7-methoxy-3-(3-trifluoromethylphenyl)-napht-1-yl)ethyl]iodoacetamide | IC50: 0.045 mM | Homo sapiens | |
N-[2-(7-methoxy-8-propenyl-napht-1-yl)ethyl]-iodoacetamide | IC50: above 0.1 mM | Homo sapiens | |
N-[2-(7-methoxy-napht-1-yl)ethyl]bromoacetamide | IC50: 0.002 mM | Homo sapiens | |
N-[2-(7-propoxy-napht-1-yl)ethyl]iodoacetamide | IC50: 0.0042 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme catalyzes the rate-limiting step in melatonin synthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + phenylethylamine | - |
Homo sapiens | CoA + N-acetyl-phenylethylamine | - |
? | |
additional information | the enzyme catalyzes the rate-limiting step in melatonin synthesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arylalkylamine N-acetyltransferase | - |
Homo sapiens |
serotonin N-acetyltransferase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00018 | - |
IC50: 0.00018 mM | Homo sapiens | N-[2-(5-hydroxy-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | |
0.00018 | - |
IC50: 0.00018 mM | Homo sapiens | N-[2-(5-chloro-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | |
0.00039 | - |
IC50: 0.00039 mM | Homo sapiens | 2-bromo-N-[2-(5-fluoro-1-benzothien-3-yl)ethyl]acetamide | |
0.0006 | - |
IC50: 0.0006 mM | Homo sapiens | N-[2-(3-ethyl-7-methoxy-napht-1-yl)ethyl]iodoacetamide | |
0.00071 | - |
IC50: 0.00071 mM | Homo sapiens | N-[2-(5-ethyl-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | |
0.00072 | - |
IC50: 0.00072 mM | Homo sapiens | N-[2-(7-hydroxy-naphth-1-yl)ethyl]bromoacetamide | |
0.001 | - |
IC50: 0.001 mM | Homo sapiens | N-[2-(2-phenyl-benzo [b]thiophen-3-yl)ethyl]bromoacetamide | |
0.0014 | - |
IC50: 0.0014 mM | Homo sapiens | bromoacetyltryptamine | |
0.00177 | - |
IC50: 0.00177 mM | Homo sapiens | N-[2-(7-ethyl-napht-1-yl)ethyl]-bromoacetamide | |
0.002 | - |
IC50: 0.002 mM | Homo sapiens | N-[2-(7-methoxy-napht-1-yl)ethyl]bromoacetamide | |
0.002 | - |
IC50: 0.002 mM | Homo sapiens | N-[2-(5-ethyl-1-benzothien-3-yl)ethyl]-2-iodoacetamide | |
0.00225 | - |
IC50: 0.00225 mM | Homo sapiens | methyl 3-[2-[(bromoacetyl)amino]ethyl]-1-benzothiophene-5-carboxylate | |
0.00378 | - |
IC50: 0.00378 mM | Homo sapiens | N-[2-(5-bromo-benzo[b]thiophen-3-yl)ethyl]bromoacetamide | |
0.0042 | - |
IC50: 0.0042 mM | Homo sapiens | N-[2-(7-propoxy-napht-1-yl)ethyl]iodoacetamide | |
0.0056 | - |
IC50: 0.0056 mM | Homo sapiens | N-[2-(5-fluoro-1H-indol-3-yl)ethyl]bromoacetamide | |
0.0087 | - |
IC50: 0.0087 mM | Homo sapiens | N-[2-(2-benzyl-5-methoxy-benzofuran-3-yl)ethyl]iodoacetamide | |
0.045 | - |
IC50: 0.045 mM | Homo sapiens | N-[2-(7-methoxy-3-(3-trifluoromethylphenyl)-napht-1-yl)ethyl]iodoacetamide | |
0.1 | - |
IC50: above 0.1 mM | Homo sapiens | N-[2-(7-ethyl-1,2,3,4-tetrahydronapht-1-yl)ethyl]iodooacetamide | |
0.1 | - |
IC50: above 0.1 mM | Homo sapiens | N-[2-(7-methoxy-8-propenyl-napht-1-yl)ethyl]-iodoacetamide |