Literature summary for 2.3.1.87 extracted from

Ferry, G.; Loynel, A.; Kucharczyk, N.; Bertin, S.; Rodriguez, M.; Delagrange, P.; Galizzi, J.P.; Jacoby, E.; Volland, J.P.; Lesieur, D.; Renard, P.; Canet, E.; Fauchere, J.L.; Boutin, J.A.
Substrate specificity and inhibition studies of human serotonin N-acetyltransferase (2000), J. Biol. Chem., 275, 8794-8805.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Melatonin	IC50 0.16 mM	Homo sapiens
additional information	inhibition values of peptide inhibitors	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.11	-	tryptamine	-	Ovis aries
0.125	-	serotonin	-	Ovis aries
0.173	-	beta-phenylethylamine	-	Homo sapiens
0.18	-	acetyl-CoA	-	Ovis aries
0.2	-	5-methoxytryptamine	-	Homo sapiens
0.55	-	acetyl-CoA	-	Homo sapiens
0.91	-	tryptamine	-	Homo sapiens
1.23	-	serotonin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme	-
Ovis aries	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + 5-methoxytryptamine	-	Homo sapiens	CoA + N-acetyl-5-methoxytryptamine	-	?
acetyl-CoA + beta-phenylethylamine	-	Homo sapiens	CoA + N-(2-phenylethyl)-acetaminde	-	?
acetyl-CoA + beta-phenylethylamine	-	Ovis aries	CoA + N-(2-phenylethyl)-acetaminde	-	?
acetyl-CoA + serotonin	i.e. 5-hydroxytryptamine	Homo sapiens	CoA + N-acetylserotonin	-	?
acetyl-CoA + serotonin	i.e. 5-hydroxytryptamine	Ovis aries	CoA + N-acetylserotonin	-	?
acetyl-CoA + tryptamine	-	Homo sapiens	CoA + N-acetyltryptamine	-	?
acetyl-CoA + tryptamine	-	Ovis aries	CoA + N-acetyltryptamine	-	?
acetyl-CoA + tyramine	very poor substrate	Homo sapiens	CoA + N-acetyltyramine	-	?
additional information	-	Ovis aries	?	-	?
additional information	further substrates: selected synthetic amines	Homo sapiens	?	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.16	-	IC50 0.16 mM	Homo sapiens	Melatonin

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Release 2023.1 (January 2023)